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Career Outcomes 85 students graduated between 2005 and 2013: 1 graduate is seeking employment; for 8 we have no data (based on research conducted between Feb-May 2016).For the remaining 76 graduates: RI (Research-Intensive) Faculty: typically tenure-track faculty positions (equivalent of the North American Assistant Professor, Associate Professor, and Professor positions) in PhD-granting institutions TI (Teaching-Intensive) Faculty: typically full-time faculty positions in colleges or in institutions not granting PhDs, and teaching faculty at PhD-granting institutions Term Faculty: faculty in term appointments (e.
sessional lecturers, visiting assistant professors, etc How to Find a Job in Statistics Advice for Students and Recent nbsp.sessional lecturers, visiting assistant professors, etc.
) Sample Employers in Higher Education University of British Columbia (15) McGill University (2) Biomarker Program Manager PhD Career Outcome Survey You may view the full report on career outcomes of UBC PhD graduates on .Disclaimer These data represent historical employment information and do not guarantee future employment prospects for graduates of this program.They are for informational purposes only 7:30 AM - 12:30 PM (CT) - e-LAB Solutions Suite 9:15 - 10:00 AM (CT) - Online Store. Portlet Component Result Form Data Entry Review, Submit & Print PT Results; » Proficiency Testing Claim CME/CE Credit for Faxed AP Results; » Competency Assessment Program Access Competency Courses. Portlet Component ID : .
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Data were collected through either alumni surveys or internet research.Career Options An Experimental Pathology degree opens up a world of opportunities.Because of the multidisciplinary nature of our program, graduates are working on research all over the world that is personalized to their interests.Our alumni have gone on to become national and international opinion leaders, valued staff researchers and administrators in academia or the biotechnology industry, studied clinical medicine or dived into the venture capital and equities domain.
Alumni on Success This program has a graduation rate of 87.
5% based on 16 students admitted between 2004 - 2007.Based on 12 graduations between 2013 - 2016 the minimum time to completion is 3.Disclaimer Admissions data refer to all UBC Vancouver applications, offers, new registrants for each year, May to April data updated: 12 July 2017 .Enrolment data are based on March 1 snapshots.Program completion data are only provided for datasets comprised of more than 4 individuals.Rates and times of completion depend on a number of variables (e.
curriculum requirements, student funding), some of which may have changed in recent years for some programs data updated: 29 September 2017 .Upcoming Doctoral Exams Sara Saberi Dynamics of Telomere Length and Mitochondrial DNA Content in a Cohort Study of HIV-Infected and HIV-Uninfected Pregnant Women and Cell Culture Models Research Supervisors This list shows faculty members with full supervisory privileges who are affiliated with this program.It is not a comprehensive list of all potential supervisors as faculty from other programs or faculty members without full supervisory privileges can request approvals to supervise graduate students in this program.Allard, Michael (Control of energy metabolism in normal and pathologic hearts; Physiologic and Pathologic Cardiac hypertrophy; Contribution of Metabolism to myocardial dysfunction after ischemia and reperfusion, especially in the setting of cardiac hypertrophy; Cardiovascular Pathology) Dr.
Burrows identified and characterized a vitamin A responsive transcription factor expressed in immune cells of the intestine and uncovered its role in the development of inflammatory bowel disease.Fernando investigated the role of extracellular vesicles in Amyotrophic Lateral Sclerosis or ALS.
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Her findings revealed that specific vesicle populations are capable of transmitting protein misfolding to recipient cells.This research provides novel evidence for the role of extracellular vesicles in human ALS disease.Qiu studied the interplay of heart cells and coxsackievirus B3, a virus causing lethal heart diseases Establishing Reference Intervals for Clinical Laboratory Test Results nbsp.
Qiu studied the interplay of heart cells and coxsackievirus B3, a virus causing lethal heart diseases.
He clarified the modulation and role of two cardiac proteins in supporting viral survival.His research advances our understanding of viral infection in the heart and provides potential drug targets for the treatment of infectious heart diseases Contrasting state-of-the-art automatic scoring of essays: Analysis. Paper presented at the annual meeting of the National Council of Measurement in Education, Vancouver, BC, Canada. Singer, S. R., Hilton, M. L., 8 Schweingruber, H. A. (Eds.). (2006). America's lab report: Investigations in high school science. Washington .His research advances our understanding of viral infection in the heart and provides potential drug targets for the treatment of infectious heart diseases.Rolinda Louise Raphaelle Carter "Blood clots affect millions of people every day Contrasting state-of-the-art automatic scoring of essays: Analysis. Paper presented at the annual meeting of the National Council of Measurement in Education, Vancouver, BC, Canada. Singer, S. R., Hilton, M. L., 8 Schweingruber, H. A. (Eds.). (2006). America's lab report: Investigations in high school science. Washington .Rolinda Louise Raphaelle Carter "Blood clots affect millions of people every day.Carter identified a novel mechanism by which new generation anticoagulants enhance the breakdown of clots englishwritinghelp.com/report.php.Carter identified a novel mechanism by which new generation anticoagulants enhance the breakdown of clots.Her findings are of particular interest in the treatment of thrombosis englishwritinghelp.com/report.php.Her findings are of particular interest in the treatment of thrombosis.Klein-Bosgoed studied protein synthesis in anucleate blood platelets.
She investigated a technology based on UV light and vitamin B2 that is designed to kill potential pathogens in blood products.Her findings will lead to the advancement of blood safety in transfusion medicine." (November 2017) Sample Thesis Submissions A supervisor is a faculty member who mentors a graduate student in their research.Many research-based graduate programs expect students to identify a prospective supervisor prior to applying for admission.It is best to check with the graduate program you will be applying to, to find out if this is expected.
If so, you will need to identify a potential supervisor in your desired field of research.As a comprehensive university with more than 12,000 faculty and staff members, including over 2,000 potential supervisors, there is a high probability that UBC will have a supervisor for your research interests.Supervisor Search Here are some tips for finding a prospective supervisor at UBC Vancouver: Check the program websites.Most programs provide lists of faculty members/potential supervisors and their research interests on their website.Follow program instructions on how best to approach potential supervisors.
UBC Faculties provide directories for their researchers: Abstract Reference intervals are essential for clinical laboratory test interpretation and patient care.Methods for estimating them are expensive, difficult to perform, often inaccurate, and nonreproducible.A computerized indirect Hoffmann method was studied for accuracy and reproducibility.The study used data collected retrospectively for 5 analytes without exclusions and filtering from a nationwide chain of clinical reference laboratories in the United States.
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The accuracy was assessed by the comparability of reference intervals as calculated by the new method with published peer-reviewed studies, and reproducibility was assessed by the comparability of 2 sets of reference intervals derived from 2 different data sets.
There was no statistically significant difference between the calculated and published reference intervals or between the 2 sets of intervals that were derived from different data sets.A computerized Hoffmann method for indirect estimation of reference intervals using stored test results is proved to be accurate and reproducible Order a lab report statistics Sophomore British 4 days Proofreading.A computerized Hoffmann method for indirect estimation of reference intervals using stored test results is proved to be accurate and reproducible.
It is hard to underestimate the importance of clinical laboratory test results.Nearly 80% of physicians’ medical decisions are based on information provided by laboratory reports Doctor of Philosophy in Pathology and Laboratory Medicine PhD.Nearly 80% of physicians’ medical decisions are based on information provided by laboratory reports.1 A test result by itself is of little value unless it is reported with the appropriate information for its interpretation Doctor of Philosophy in Pathology and Laboratory Medicine PhD.
1 A test result by itself is of little value unless it is reported with the appropriate information for its interpretation.
Typically, this information is provided in the form of a reference interval (RI) or medical decision limit.An RI as defined by Ceriotti “is an interval that, when applied to the population serviced by the laboratory correctly includes most of the subjects with characteristics similar to the reference group and excludes the others.” 2(p115) No RI is completely “right” or “wrong.” The majority of RIs in use today refer to the central 95% of the reference population of subjects.By definition, 5% of all results from “healthy” people will fall outside of the reported RI and, as such, will be flagged as being “abnormal.
” There are many problems associated with the calculation of RI.The latest edition of the Clinical and Laboratory Standards Institute–approved guideline, “Defining, Establishing, and Verifying Reference Intervals in the Clinical Laboratory,” recognizes the difficulties and controversies surrounding the establishment of RIs and the verification process: “…the working group recognizes the reality that, in practice, very few laboratories perform their own reference interval studies,” “…instead of performing a new reference interval study, laboratories and manufacturers refer to studies done many decades ago, when both the methods and the population were very different.” 3(p1) It has been recommended that an RI be established by selecting a statistically sufficient group (a minimum of 120) of healthy reference subjects.However, it is noted in the guideline that “Health is a relative condition lacking a universal definition.Defining what is considered healthy becomes the initial problem in any study….
” 3(p8) In reality, there will always be some level of uncertainty with a given selection protocol not only because of the definition of health that was selected but also because of the very real possibility that some of the selected subjects may, in fact, have subclinical disease.Recruiting a valid group of reference subjects and obtaining informed consent in today’s environment is costly, time-intensive, and virtually an impossible task for most laboratories.The challenge is further magnified in establishing RIs for different age groups (eg, pediatric patients and geriatric patients), uncommon sample types (eg, cerebrospinal fluid and aspirations), timed collections, challenge tests, and serial measurements.In light of these difficulties, most laboratories elect not to establish their own RIs, but rather choose to verify RIs that have been reported by the manufacturer or as established by another laboratory.This is a relatively simple study and requires only 20 healthy subjects to recruit.
3 The underlying assumption here is that the laboratory analytic system is calibrated and producing similar results as the method that was originally used in the published RIs.However, this may not be true because in many cases, the details of the reference study such as its design, the inclusion and exclusion criteria used for selecting the healthy recruits, preanalytic sources of variation, etc, are lacking.
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A laboratory can elect to “transfer” the RIs that were in use with an older method (or from another laboratory) to a new method.To do this, the laboratory must first demonstrate that the 2 methods produce comparable results.It is well known that analytic systems drift over time, and there is no guarantee that the method of today is producing results that are comparable to those that were produced at the time of the original RI study Best websites to purchase statistics lab report 100% original British single spaced Standard Business.
It is well known that analytic systems drift over time, and there is no guarantee that the method of today is producing results that are comparable to those that were produced at the time of the original RI study.
This technique is the main reason why many laboratories today are using RIs that were established decades ago and are out-of-date.Even if a laboratory was able to obtain a rigorously selected statistically sufficient number of healthy subjects and perform all the necessary testing, the next step would require statistical analysis of data.What statistical technique should be used: parametric, transformed parametric, non-parametric, or many others described? The judgment in most cases will be made subjectively because there are no clear guidelines, and the resultant intervals will differ depending on the method used (Manuscript in Harry Hawthorn Papers, Special Collections Division, University of British Columbia, Vancouver.) Hoard, James E. Sacramento Anthropological Society Paper 1 1 . Sacramento. Hofmeister, Jon Fredrick 1968 A Statistical Analysis of Culture Change among Fourteen Plateau and California Indian Groups..What statistical technique should be used: parametric, transformed parametric, non-parametric, or many others described? The judgment in most cases will be made subjectively because there are no clear guidelines, and the resultant intervals will differ depending on the method used.Laboratories are often faced with test data that exhibit a multimodal or an asymmetric distribution.This may reflect a large prevalence of subclinical disease within the selected population or subgroup-related differences in normal ranges.
The latter requires partitioning of test subjects by sex, age, race, and other factors.Partitioning by sex is relatively easy (select a minimum of 120 males and 120 females).However, partitioning by age groups is not a simple matter.What age cutoffs should be used? How many groups should be studied? There are some complex statistical techniques available, but none seem ideal for solving partitioning problems.In the modern environment when laboratories are struggling to stay profitable, not everyone is willing to budget the appropriate resources for a lengthy and expensive RI study.An alternative approach for establishing RIs is to do an indirect so-called a posteriori study of the patient data already collected and stored in the laboratory database.This is appealing because the data are readily available and will result in time and cost savings.A number of publications discuss this approach.4–8 Most of these studies were able to report clinically relevant and meaningful RIs.
All of them used various sophisticated filters to exclude results from “unhealthy” subjects, and some used data from hospital laboratories and some from outpatient care settings or noninstitutionalized population study databases.Most of these studies used complex statistical algorithms to derive the final intervals.However, current guidelines do not endorse these methods as a primary approach for establishing RIs, mainly out of concern for the fact that most of the data may not come from reference or healthy subjects.3 This position may be justified for test results collected from hospitalized patients but is questionable when considering a very large number of results that have been collected in outpatient settings.Indeed, there is no disease with prevalence close to 50%.
On the other hand, as discussed, the recommended direct sampling techniques are not without their own assumptions.
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Statistically, it is more robust to analyze thousands of measurements that may include some unhealthy subjects than 120 measurements that are assumed to be from healthy subjects.The main problem with most of the reported indirect studies is that they used statistical analyses designed for a direct sampling technique.
Hoffmann, in his classic JAMA article from 1963, described a technique designed for indirect estimation of RIs using all available test results from a laboratory’s database: “This statistical technique can be used for obtaining any normal values in medicine where a group of measurements are available and the mathematical assumptions are reasonable Finding a Supervisor Graduate School University of British nbsp.
Hoffmann, in his classic JAMA article from 1963, described a technique designed for indirect estimation of RIs using all available test results from a laboratory’s database: “This statistical technique can be used for obtaining any normal values in medicine where a group of measurements are available and the mathematical assumptions are reasonable.
” 9(p868) Although his work has been widely cited, few authors have actually applied the Hoffmann method in their calculations.A notable exception is the manual of pediatric RIs by Soldin et al 10 that is now in its sixth edition and published by American Association for Clinical Chemistry 13 Jan 2014 - Introduction A graduate student in statistics recently asked me for advice on how to find a job in our industry. I'm happy It is harder to find a job in statistics in a smaller or less industrious city like Vancouver, where I currently work. I offer this following advice as an anglophone working in North America..A notable exception is the manual of pediatric RIs by Soldin et al 10 that is now in its sixth edition and published by American Association for Clinical Chemistry.This fundamental work was limited by the relatively small number of observations (typically 50–100) that were used and by the semimanual application of Hoffmann analysis of data, which added subjectivity to the calculations 13 Jan 2014 - Introduction A graduate student in statistics recently asked me for advice on how to find a job in our industry. I'm happy It is harder to find a job in statistics in a smaller or less industrious city like Vancouver, where I currently work. I offer this following advice as an anglophone working in North America..This fundamental work was limited by the relatively small number of observations (typically 50–100) that were used and by the semimanual application of Hoffmann analysis of data, which added subjectivity to the calculations.10 Our goal in this study was to assess the reliability of the Hoffmann approach using a newly developed computer program designed to remove subjectivity from RI calculations term paper.10 Our goal in this study was to assess the reliability of the Hoffmann approach using a newly developed computer program designed to remove subjectivity from RI calculations.Materials and Methods Participants The study was carried out using the data from Laboratory Corporation of America, one of the largest providers of laboratory testing in the United States englishwritinghelp.com/term-paper.php.
Materials and Methods Participants The study was carried out using the data from Laboratory Corporation of America, one of the largest providers of laboratory testing in the United States.
Data were collected from 6 regional laboratories: Burlington, NC; Columbus, OH; Houston, TX; Birmingham, AL; Raritan, NJ; and Tampa, FL.The average ordering source by test volume for this group of laboratories was as follows: 87% from outpatient general practice facilities and 13% from acute care facilities.The patient test results stored in the laboratory information system were queried for a given time frame without any filtering, no results were excluded, and all of these results constituted the original database for this study.The protocol for this study was determined to be exempt under existing regulations by the institutional review board.Accuracy Study The following 5 analytes were evaluated: mean corpuscular volume (MCV), hemoglobin, creatinine, calcium, and thyroid-stimulating hormone (TSH).
Each of these analytes are known to have peer-reviewed RIs as calculated from direct sampling of volunteers, multicentered studies, or national survey databases.The following numbers of test results were collected retrospectively from the laboratory information system: MCV, 40,744 results (men and women); hemoglobin, men, 16,463; hemoglobin, women, 24,809; creatinine, men, 24,068; creatinine, women, 29,471; calcium, 51,492 (men and women); and TSH, 129,443 (men and women).All results originated from tests performed in June 2008 and were from adult patients (18 years or older).Reproducibility Study The reproducibility of this method was assessed using TSH as an analyte that historically has been problematic for RI studies.Some authors have suggested that “TSH reference range cannot be determined from population data, because occult thyroid dysfunction skews the TSH upper limit.
” 11(p4239) A comparison of 2 TSH RIs as calculated from 2 different sets of test results collected 6 months apart was considered to be a good challenge for testing the reproducibility of this method.The second set of TSH results (n = 151,235) from adult patients (18 years or older) originated from December 2008 was collected.Technical Information Standardization to the same methods, reagent lot numbers, calibrators, controls, and standard operating procedures significantly reduces the between-laboratory variability in test results.All 6 laboratories that participated in this study had been standardized in this manner.The methods were as follows: MCV and hemoglobin, LH750/GEN*S (Beckman Coulter, Miami, FL); creatinine and calcium, Roche/Hitachi MODULAR (Roche Diagnostics, Indianapolis, IN); TSH, ADVIA Centaur (Siemens Medical Solutions Diagnostics, Tarrytown, NY).
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All methods are US Food and Drug Administration–approved and were operated according to the manufacturer’s specifications.Centralized comparative method performance monitoring for each laboratory location was conducted on a monthly basis using quality control data and patient mean data.Statistical Analyses The Hoffmann indirect method for the derivation of RIs was programmed as originally described Handbook of North American Indians V 12 Plateau.Statistical Analyses The Hoffmann indirect method for the derivation of RIs was programmed as originally described.
9 Chauvenet criteria were used for the detection and elimination of outliers.With Chauvenet criteria, a measurement (result) is eliminated if the probability of its occurrence is less than 1/(2N), where N is the number of measurements in the data pool and is greater than 4 The medical laboratory technologist performs laboratory investigations related to the diagnosis, treatment, and prevention of disease, including analysis of a variety of specimens such as blood, urine, This program is competitive and only applicants who have met the academic entrance requirements will be considered..
With Chauvenet criteria, a measurement (result) is eliminated if the probability of its occurrence is less than 1/(2N), where N is the number of measurements in the data pool and is greater than 4.
Following the elimination of outliers, the cumulative frequency for each test result was determined.The frequency of a test result was taken as the number of times a result occurs in the data set divided by the total number of results times 100%.Once the outliers had been eliminated, the data were refined so that only values from the linear portion of the cumulative frequency graph were used.Visual analysis provides a good approximation of the linear data so that only values from the linear portion of the cumulative frequency graph were used.
By computing the maximum deviation of the data from the regression line in this interval, the acceptable linearity error may be defined.This approach was taken because it is the best way to translate human fuzzy logic into computer precision.Once the acceptable linearity error had been defined, the portion of the data pool that was deemed to be “linear” was selected and used in computing the associated regression line Figure 1.Subsequently, the best-fitting linear regression ( y / 2where Z is the probability selected for significance (a Z value of 1.96 was selected for 95% probability corresponding to a significant change), CV a is the analytic variation, and CV i is the within-subject biologic variation.
The CV a and CV 13 Results The representative output graph is given in Figure 2, and the derived regression functions and calculated RIs for all 5 analytes are given in Table 1.The comparison of calculated RIs using the computerized Hoffmann method with peer-reviewed published intervals is given in Table 2 (accuracy study).14–18 The comparison of 2 sets of TSH RIs derived from 2 separate data sets collected 6 months apart are given in the Table 3 (reproducibility study).Figure 1 A, Cumulative frequencies (dots) and regression line.B, Scatter graph showing good data (black dots) and outliers (gray dots).67008; N value, 16,457 (without outliers); regression function, y = 0.To convert hemoglobin values to Syst me International units (g/L), multiply by 10.Discussion The computerized Hoffmann method for the indirect determination of RIs produced intervals that were remarkably similar to peer-reviewed RIs (Table 2).14–18 None of the calculated lower or upper limits displayed statistically significant differences from the corresponding published limits.
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Table 1 Regression Functions and Calculated Reference Intervals for Five Analytes as Determined by the Computerization of the Hoffmann Method for the Indirect Estimation of Reference Intervals Table 2 Comparison of Reference Intervals as Calculated by the Hoffmann Method With RIs as Reported in the Literature (Accuracy Study) Table 3 Comparison of RIs as Calculated by the Hoffmann Method for Two Sets of TSH Data Collected 6 Months Apart (Reproducibility Study) The calculated ranges in most cases were slightly narrower than the ranges obtained from direct sampling techniques.A concern with the use of indirect methods has been that the resulting interval may be wider than it should be or skewed because of inclusion of unhealthy subjects.This was not observed in the present study Introduction. As a graduate student, conducting research and publishing your work is essential to your will also find materials and resources that outline a variety of issues and topics related to authorship. biomedical field it is customary for the advisor (as head of the lab) to be the last author. It is therefore all the more .This was not observed in the present study.
It is noteworthy that the choice of the statistical method and the large number of observations are critical components in maintaining the accuracy of RIs derived from indirect methods.The described technique may be the method of choice for this purpose A supervisor is a faculty member who mentors a graduate student in their research. Many research-based graduate programs expect students to identify a prospective supervisor prior to applying for admission. It is best to check with the graduate program you will be applying to, to find out if this is expected. If so, you will .
The described technique may be the method of choice for this purpose.
It is well recognized that test results may be impacted by a host of different factors, some of which are known and some are not (preanalytic sources of variation).Preanalytic sources of variation should be taken into consideration and controlled when selecting the healthy subjects who will be used for establishing an RI by traditional techniques.Despite this, preanalytic sources of variation that may have been controlled for in establishing the RI are often neglected when it comes to the routine testing of patients.It may be argued that the Hoffmann indirect technique as applied in the present study should provide a more robust estimation of the RI than traditional methods in that the majority (if not all) of the preanalytic sources of variation impacting the test result will be reflected in the outcome.Another interesting aspect from this study relates to estimates of disease prevalence.
It is reasonable to suggest that the percentage of test results above and below the upper and lower limits in the entire data set used for RI calculation for a given analyte may correlate with a prevalence of conditions that cause its concentration to be abnormal.This assumption is less reasonable while using smaller sets of patient results or results from hospital settings because the results distribution will be skewed by the significant number of repeated tests from the same patient and results from patients with serious conditions.The large number of observations from outpatient settings will negate those factors.A recent study of the prevalence of chronic kidney disease in the United States reported the prevalence in 1999 to 2004 as 13.1% and raised concerns about its future increase.
19 In the present study, the filtering technique excluded from the healthy subgroup a total of 14.4% of test results for creatinine as being above the calculated upper range (men and women).This mirrors the reported prevalence of kidney disease in the United States.The American Thyroid Association has estimated the prevalence of thyroid dysfunction in the United States for subclinical hypothyroidism to be up to 17% and for clinical hypothyroidism to be up to 2%, which makes a combined prevalence of both hypothyroid conditions of up to 19%.The prevalence of subclinical hyperthyroidism was reported to be up to 6% and clinical hyperthyroidism to be up to 0.
2%, which makes a combined prevalence of both hyperthyroid conditions of up to approximately 6%.20 The described method excluded from the healthy subgroup a total 18.6% of test results for TSH that were above the calculated upper limit and 5.
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9% of test results for TSH that were below the calculated lower limit of the RI.Again, these values are very close to the reported prevalence of thyroid diseases.
As expected, the reported RIs for TSH showed the greatest degree of variation with the reference studies A Graduate Student s Guide to Determining Authorship Credit and nbsp.As expected, the reported RIs for TSH showed the greatest degree of variation with the reference studies.
However, the observed difference was well below the RCV.It is interesting that both of the reference studies for TSH reported higher upper limits than the upper limit that was generated in the present study.This may be explained in part by the observations of Spencer et al 11 regarding the difficulties in the estimation of an accurate TSH upper limit using the existing techniques.The presented method seems to accurately reflect the actual distribution of TSH in the thyroid disease–free population, and the new calculated TSH upper limit is in complete agreement with a recently suggested upper limit of 3.
0 mIU/L and a treatment goal for hypothyroidism.21,22 The limitations of this method for the use in many clinical laboratories may apply when one of the following is present: a large prevalence of results from hospitalized patients; a limited number of observations, especially for subject groups like pediatric or geriatric patients or rare sample types like synovial fluid; and lack of standardization between the methods in use.This limitation could be minimized by linking laboratories that are operating similar instrumentation and methods into peer group–based operational networks.The performance of the peer group within the network would be monitored to ensure that standardization goals are being met.Under such circumstances, each of the participating laboratories could contribute its patient test results to a central network data bank from which the RIs for the network could be established.
Conclusions The described computerized Hoffmann method for the indirect estimation of the RIs from the existing laboratory database of test results has proven to be reliable and reproducible.The method produced RIs that were statistically not different from the ones reported in peer-reviewed publications.This method was able to derive RIs for a problematic analyte (TSH), producing a result that was in strong agreement with recent scientific observations and clinical recommendations.In addition to its reliability and reproducibility, this technique has a number of advantages over the conventional direct sampling techniques.Notably, it provides a mechanism for deriving RIs for difficult-to-study populations like pediatric and geriatric, as well as for rare sample types like aspirations, for calculating RIs for timed collections, and for challenge tests while providing overall laboratory resources savings.
In addition, it may be used on an ongoing basis as part of a quality management program by providing an auditing tool for confirming the appropriateness of the current RIs for the existing methods.The caveat for this method is that it may be used only with large numbers of observations, with test results that are mostly from outpatient settings, and when standardization of methods has been implemented and monitored.We thank Mark Sharp for the collection of data and Mark Brecher, MD, for review of the manuscript.References Utah Governor Huntsman recognizes medical laboratory week.